Effect of water flow and chemical environment on microbiota growth and composition in the human colon

Jonas Cremer*, Markus Arnoldini*, Terence Hwa: Effect of water flow and chemical environment on microbiota growth and composition in the human colon. In: Proceedings of the National Academy of Science of the United States of America, 114 (25), pp. 6438–6443, 2017, ISSN: 0027-8424.

Abstract

The human gut is populated by a dense microbial population, strongly impacting health and disease. Metagenomic sequencing has led to crucial insights into microbiota changes in response to various perturbations, but a mechanistic understanding of these changes is largely missing. As the composition of the gut microbiota is a consequence of bacterial growth, we propose an approach that focuses on bacterial growth in the human large intestine and the physiological factors influencing it. Using a combination of experimental analysis and quantitative simulations, we explain the observed variation in microbiota composition among healthy humans and the dominant role of nutrient inflow and stool consistency. Our quantitative modeling framework is a step toward a predictive understanding of microbiota dynamics in the human host.

BibTeX (Download)

@article{2017,
title = {Effect of water flow and chemical environment on microbiota growth and composition in the human colon},
author = {Jonas Cremer* and Markus Arnoldini* and Terence Hwa},
doi = {10.1073/pnas.1619598114},
issn = {0027-8424},
year  = {2017},
date = {2017-01-01},
journal = {Proceedings of the National Academy of Science of the United States of America},
volume = {114},
number = {25},
pages = {6438--6443},
publisher = {NATL ACAD SCIENCES},
abstract = {The human gut is populated by a dense microbial population, strongly impacting health and disease. Metagenomic sequencing has led to crucial insights into microbiota changes in response to various perturbations, but a mechanistic understanding of these changes is largely missing. As the composition of the gut microbiota is a consequence of bacterial growth, we propose an approach that focuses on bacterial growth in the human large intestine and the physiological factors influencing it. Using a combination of experimental analysis and quantitative simulations, we explain the observed variation in microbiota composition among healthy humans and the dominant role of nutrient inflow and stool consistency. Our quantitative modeling framework is a step toward a predictive understanding of microbiota dynamics in the human host.},
keywords = {colon physiology, colonic pH, gut microbiota, stool consistency, water absorption},
pubstate = {published},
tppubtype = {article}
}