Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel

Jonas Cremer*, Igor Segota*, Chih-yu Yang, Markus Arnoldini, John T Sauls, Zhongge Zhang, Edgar Gutierrez, Alex Groisman, Terence Hwa: Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. In: Proceedings of the National Academy of Science of the United States of America, 113 (41), pp. 11414–11419, 2016, ISSN: 0027-8424.

Abstract

The human colon is occupied by trillions of microbial cells. Recent sequencing studies have shown that many diseases lead to substantial changes in the composition of this gut microbiota and suggest a strong influence of composition on host physiology. However, not much is known about the underlying physiological factors shaping the gut microbiota. Here, we focus on the role of flow and mixing by colonic wall contractions. To grow in the proximal colon, microbes have to continuously overcome flow. Our in vitro study suggests that mixing helps to overcome flow, and controlled contractions by the colon strongly influence microbiota density and composition; flow and mixing are essential components toward developing a predictive understanding of the gut microbiota.

BibTeX (Download)

@article{2016,
title = {Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel},
author = {Jonas Cremer* and Igor Segota* and Chih-yu Yang and Markus Arnoldini and {John T } Sauls and Zhongge Zhang and Edgar Gutierrez and Alex Groisman and Terence Hwa},
doi = {10.1073/pnas.1601306113},
issn = {0027-8424},
year  = {2016},
date = {2016-01-01},
journal = {Proceedings of the National Academy of Science of the United States of America},
volume = {113},
number = {41},
pages = {11414--11419},
publisher = {NATL ACAD SCIENCES},
abstract = {The human colon is occupied by trillions of microbial cells. Recent sequencing studies have shown that many diseases lead to substantial changes in the composition of this gut microbiota and suggest a strong influence of composition on host physiology. However, not much is known about the underlying physiological factors shaping the gut microbiota. Here, we focus on the role of flow and mixing by colonic wall contractions. To grow in the proximal colon, microbes have to continuously overcome flow. Our in vitro study suggests that mixing helps to overcome flow, and controlled contractions by the colon strongly influence microbiota density and composition; flow and mixing are essential components toward developing a predictive understanding of the gut microbiota.},
keywords = {bacterial growth, colon microbiota, in vitro gut model, peristalsis, reaction-diffusion model},
pubstate = {published},
tppubtype = {article}
}